GPAT Organic Chemistry Syllabus 2021 – Get Syllabus PDF Here


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GPATThe National Testing Agency is shortly known as NTA and it is conducted the GPAT 2021 Examination, which is commonly known as the Graduate Pharmacy Aptitude Test. There is many of the candidates may appear for this examination every year.

Those candidates are interested to get admission in the medical courses, they can fill the application form of GPAT and through this examination result, and the candidates will be eligible and go for the counseling procedure.

Here, through this article, the candidates will be able to know the complete information of GPATin which includes GPAT 2021 Syllabus.

GPAT Organic Chemistry Syllabus – PDF Available

New GPAT 2021 Organic Chemistry Syllabus is Available. Click Here to Download PDF.

Organic Chemistry

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General Principles: A brief review of classification & sources of organic compounds, sp3, sp2, sp hybridization, sigma & pi- bonds, bond lengths, bond angles & bond energies along with their significance in reactions should be carried out. An overview of bond polarization, hydrogen bonds, inductive effects, resonance, and hyperconjugation be taken. The concept of homolytic & heterolytic bond fission, acidity & basicity with different theories should be covered briefly. Ease of formation & order of stabilities of electron-deficient & electron-rich species along with the reasons for the same should be covered. Relationships between energy content, stability, reactivity & their importance in chemical reactions should be covered. Calculations for determining empirical & molecular formula should be covered.

Different Classes of Compounds: The following classes of compounds should be taught in detail with respect to their IUPAC / systematic nomenclature, industrial [wherever applicable] & laboratory methods of preparations, physical properties & chemical reactions with emphasis on reaction mechanisms [arrow based] & stereochemistry [wherever applicable].

  • Alkanes [including cyclic compounds]
  • Alkenes [including cyclic compounds]
  • Alkynes [only open-chain compounds]
  • Aliphatic hydroxyl compounds
  • Alkyl halides
  • Aldehydes & Ketones
  • Carboxylic acids
  • All functional derivatives of carboxylic acids.

Protection & Deprotection of Groups: Introduction to the protection & deprotection of functional groups. Two examples each for amino, hydroxyl, & carbonyl groups. The significance of these in syntheses should be explained.

Aromaticity & Aromatic Chemistry: The concept of aromaticity, Huckel’s rule & its use in determining the aromatic / non­aromatic character of a compound. Brief coverage of the structure of benzene. Detailed coverage of electrophilic & nucleophilic aromatic substitution reactions. Reactivity & orientation in these reactions. Reactivity & orientation in mono- & disubstituted benzenes. Benzyne mechanism.

Different Aromatic Classes of Compounds: The following classes of compounds with respect to their IUPAC / systematic nomenclature, industrial [wherever applicable] & laboratory methods of preparations, physical properties & chemical reactions with emphasis on reaction mechanisms [arrow based] & stereochemistry [wherever applicable].

  • Aromatic Hydrocarbons.
  • Phenolic compounds.
  • Aromatic & aliphatic amines.
  • Diazonium Salts.
  • Aromatic nitro- compounds, aryl halides, & others.

Polycyclic Aromatic Hydrocarbons: Syntheses & reactions with mechanisms of bi & tricyclic fused carbocyclic rings like naphthalene, anthracene, & phenanthrene.

Carbonyl Chemistry: Carbonyl chemistry involving group conversions & their reaction mechanisms along with stereochemistry wherever applicable.

  • Wolf-Kishner reduction & Huang-Minlong modification.
  • Reduction of aryl sulfonyl hydrazine/hydrazones to alkanes.
  • Bamford Steven reaction.
  • DCC Oxidation of alcohol.
  • Michael addition / 1,4-addition / conjugate addition.
  • Mannich condensation / reaction.
  • Robinson annulation.
  • Stobbe condensation.
  • Darzen’s glycidic ester synthesis.
  • Beckmann rearrangement.
  • Baeyer Villiger rearrangement.
  • Curtius, Wolff, & Lossen rearrangements.
  • Willgerodt rearrangement.
  • Pinacol-pinacolone rearrangement.
  • Methylene transfer reactions. Use of diazomethane & sulphur ylides in the same.
  • Mono- & dialkylations in 1,3-dicarbonyl compounds.
  • Formation & use of enol ethers, enol acetates & enamines as protective groups & in regiospecific alkylations.
  • Heterocyclic Chemistry

IUPAC Nomenclature of heterocyclic rings [3-10 membered] containing O, S, & N atoms. Nomenclature of the above rings containing mono-, di-, & multiple [same or different] heteroatoms should also be covered. Nomenclature of 2 & 3 fused rings containing mono-, di-, & multiple heteroatoms [same or different] should also be covered. Syntheses & reactions of three to six-membered rings in detail. Syntheses of five & six-membered rings containing mono- or any di- heteroatoms [O, S, & N]. Syntheses of quinoline, isoquinoline, benzoxazole, benzothiazole, & benzoxazole, benzotriazole, benzoxazole, & benzothiazole.

Heterocyclic Chemistry: IUPAC Nomenclature of heterocyclic rings [3-10 membered] containing O, S, & N atoms. Nomenclature of above rings containing mono-, di-, & multiple [same or different] heteroatoms should also be covered. Nomenclature of 2 & 3 fused rings containing mono-, di-, & multiple heteroatoms [same or different] should also be covered. Syntheses & reactions of three to six-membered rings in detail. Syntheses of five & six-membered rings containing mono- or any heteroatoms [O, S, & N]. Syntheses of quinoline, isoquinoline, benzoxazole, benzothiazole, & benzimidazole, benzotriazole, and benzothiazole

Bridged Rings: Bridged ring systems & their nomenclature.

Kinetic & Thermodynamic Control: Kinetic & thermodynamic control of sulfonation, enolate anion formation & alkylation of enamine reactions.

Stereochemistry: Stereochemistry. Chirality & asymmetry [introduction of the same to S, P, & N]. Definition & classification [different types of isomerisms]. Enantiomers, diastereomers. Enantiomerism & diastereomers. Meso compounds & their optical activity. Stereochemistry in acyclic compounds. Newman projection formulae & their significance. Conformational analysis of n-butane. Absolute & relative configuration. Assigning R & S configuration based on Cahn Ingold & Prelog system. Racemic mixture- its definition & resolution. Definitions of terms stereoselective, stereospecific, Enantiomeric excess & diastereomeric excess. Stereochemistry in cyclic systems. Conformations of cyclohexane. Cis-trans relationship in cyclohexane. Prediction of stability of different conformations of 1, 2- 1,3- & 1,4- disubstituted cyclohexanes. Effect of multiple substitutions on the stability of cyclohexane conformations. Chair conformations of cis-, & trans-decalins, dihydrophenanthrenes, & a tetracyclic steroidal nucleus. An introduction to atropisomerism.

Carbohydrates: Carbohydrates. Definition & classification. D & L nomenclature in sugars. Different ways of drawing / representing a sugar molecule [including cyclic Structure], interconversion of these representations. Anomers & epimers. Mutarotation. Reactions of glucose. Chain extension & chain reduction of sugar.

Amino Acids & Proteins: Amino acids & proteins. Definition & classification. D & L Amino acids, natural, essential, & non-essential amino acids. Denaturation, Strecker, Gabriel phthalimide methods for the preparation of amino acids. Peptide bond & its formation. Two protective groups each, for -NH2 & -COOH functionalities during protein synthesis. Sequencing of a protein by chemical & enzymatic methods.

Pericyclic Reactions: Pericyclic reactions. The concept of HOMO & LUMO. Drawing of HOMO & LUMO of 1, 3- butadiene, allylic cation, radical & anion, & 1, 3, 5-hexatriene. Meaning of conrotatory & disrotatory. Allowed & disallowed thermal & photochemical reactions. Introduction to sigmatropic, electrocyclic & (4n + 2) cycloaddition reactions. Cope, oxy-cope [Claisen rearrangement], Diel’s-Alder & retro Diel’s Alder reaction.

Also, Check Below-

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Pharmaceutical Chemistry

Pharmaceutics

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